Translational medicines “Ecosystem”

Translational CNS medicines research.

The major imperative of the pharmaceutical industry is to effectively translate insights gained from basic research into new medicines. This task is toughest for CNS disorders. Compared with non-CNS drugs, CNS drugs take longer to get to market and their attrition rate is greater. This is principally because of the complexity of the human brain (the cause of many brain disorders remains unknown...

Translational Devices, Technologies, and Medicines in Clinical Ophthalmology

Over the last few decades, there has been a rapid advance in the technologies contributing to clinical ophthalmology ranging from novel hardware and software to new imaging and laser modalities with the emergence of nanotechnologies and drug innovations. The stated aim of translational research is to apply discoveries from basic science to enhance medical practice and human health, with many of...

translational nanomedicine

European Medicines Agency Veterinary Medicines and Inspections

1. Ivermectin belongs to the macrocyclic lactone class of endectocides and consists of a mixture of two homologous compounds, 22,23-dihydroavermectin B1a (H2B1a, not less than 80%) and 22,23-dihydroavermectin B1b (H2B1b, not more than 20%). Avermectins are potent anthelmintic, insecticidal and acaracidal compounds which, by increasing the membrane permeability to chloride ions, mediate the para...

European Medicines Agency Veterinary Medicines and Inspections

1. Avilamycin is an orthosomycin antibiotic complex produced by the fermentation of Streptomyces viridochromogenes. Orthosomycin antibiotics are divided into two groups: those that contain an aminocyclitol residue and those that are esters of dichlorisoeverninic acid. Avilamycin falls into the latter group as do the evernimicins. Avilamycin is primarily active against gram-positive bacteria. Th...